Leading Health and Life Sciences in Nova Scotia

NEWS RELEASE: Adaptiiv’s Innovative 3D Printing Software Solution Wins $100K in Atlantic Canada’s First-Ever Health Challenge Pitch Focusing on Cancer Care


HALIFAX, NS, June 25, 2020

Adaptiiv’s Innovative 3D Printing Software Solution Wins $100K in Atlantic Canada’s First-Ever
Health Challenge Pitch Focusing on Cancer Care


Adaptiiv Medical Technologies Inc. (Adaptiiv) is proud to announce it has been named the first-ever
recipient of Atlantic Canada’s Health Challenge focusing on cancer care.

The company was recently awarded the prestigious prize as determined by a panel of judges comprised
of experts in the sectors of healthcare, technology, and government.

This undertaking will see full deployment of Adaptiiv’s innovative technology into the Nova Scotia Health
Authority’s (NSHA) clinical workflow with the goal of improving traditional processes and maximizing

Dr. Gail Tomblin Murphy, Vice President of Research, Innovation & Discovery and CNE at NSHA says:
“Working with Adaptiiv will allow the NSHA to further implement innovative technologies that improve
the accuracy and level of care that is required of our medical practitioners in order to make concise, lifesaving treatments for patients in Atlantic Canada.”

Adaptiiv’s primary focus is to improve treatment accuracy and patient care by combining its software
platform and 3D printing to design and create patient-specific radiotherapy (RT) accessories.

Past collaboration with the NSHA has allowed Adaptiiv to conduct research and development into refining
its software platform. Now, the two organizations will work toward developing a deep understanding of
the entire end-to-end clinical workflow to further incorporate innovative treatment techniques into
NSHA’s existing processes, enhance the traditional RT workflow, and develop a playbook to integrate
Adaptiiv’s technology on a broader scale across the entire industry.

“Adaptiiv provides the health authority with the ability to design and create patient-specific accessories
quickly and accurately to improve both treatment delivery and the patient experience. Our solution
integrates directly with the clinically-commissioned treatment planning system (TPS), allowing clinicians
at the NSHA to perform dose and plan verification in the TPS prior to treatment which reduces any risk of
not delivering the precise plan that was designed for the patient,” says Adaptiiv CEO, Peter Hickey.

“We are excited to continue working with the NSHA to deepen our understanding of their clinical workflow,
further integrate our 3D printing software solution to maximize workflow efficiencies, and ultimately
become the definitive standard of care,” adds Hickey.

About the Health Challenge
To further drive innovation in the MedTech space, Volta, Nova Scotia Health Authority, BioNova, QEII
Foundation, and the Atlantic Canada Opportunities Agency, have formed a strategic partnership to
present the Health Challenge, a series of five pitch events focusing on specific health care priorities.
MedTech companies participating in the competition present their technologies that aim to solve various
priorities pre-determined by the Nova Scotia Health Authority.

About Adaptiiv
Headquartered in Halifax, Nova Scotia, Canada, Adaptiiv Medical Technologies Inc. is shaping the future
of patient-specific healthcare through innovation and collaboration with industry leaders throughout the
world. With FDA 510(k) clearance and a CE Mark, Adaptiiv offers a regulatory cleared software solution
that has been fully validated to create custom 3D printed radiotherapy accessories. The company’s
solution is currently used in a clinical setting by clients in 14 countries.


Media Contact
Rohit Seth
Director, Marketing
[email protected]

Adaptiiv Wins $100K Health Challenge

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Halifax-based Adaptiiv Medical Technologies has won the Nova Scotia Health Authority’s first Health Challenge pitch competition, bagging a $100,000 prize.

Announced in February and hosted by innovation hub Volta, the Health Challenges are a series of five events aimed at identifying technologies to help modernize Nova Scotia’s aging and understaffed healthcare system. Friday’s competition was focused exclusively on cancer-related innovations.

In addition to the cash prize, the NSHA has promised to consider adopting Adaptiiv’s technology for use in the provincial medical system.

“Through this challenge, we know that we have created this space that’s supportive or collaborative in nature,” said Dr. Gail Tomblin Murphy, who is the NSHA’s vice president of research, innovation and discovery, and chief nurse executive. She added that the display of innovation shows “that the support and strength to draw from our private partners is making a difference.”

Adaptiiv sells equipment and software for 3D printing specialized bolus devices – pieces of polymer placed on patients’ bodies to target radiation therapy during cancer treatment.

Eckert & Ziegler BEBIG and Adaptiiv extend strategic partnership

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Eckert Ziegler BEBIG (EZB) and Adaptiiv Medical Technologies Inc. (Adaptiiv) are pleased to announce an extension of their strategic partnership. EZB will resell Adaptiiv’s 3D printing software solution in select markets that include Germany, Austria, Switzerland, Italy, Spain, and France. The two companies previously completed compatibility testing between their respective platforms. Adaptiiv has released new features in version 3.0 of its software solution to ensure mutual customers can use the regulated solution.

EZB is a European-based group active in the production and distribution of medical products for the treatment of cancer using brachytherapy. Brachytherapy applies radioactive sources directly to or into the tumor, allowing a high dose to the tumor while sparing the surrounding healthy tissue. For the patient, this means shorter treatment periods, fewer side effects, and a faster recovery.

NEWS RELEASE – Researchers Present New Positive Interim Data on Appili Therapeutics’ ATI-1701 Biodefense Program at 2019 Chemical and Biological Defense Science & Technology Conference

See original news release here

New data demonstrates durable protective response for Appili’s vaccine candidate against Francisella tularensis, a Category A pathogen and potential biological weapons threat

Presentation provides additional safety and efficacy data supporting use of ATI-1701 as a medical countermeasure, supports ongoing development under U.S. Food and Drug Administration’s medical countermeasure development guidelines

HALIFAX, Nova Scotia, November 18, 2019 – Appili Therapeutics Inc. (TSXV: APLI) (the Company or Appili), a biopharmaceutical company focused on anti-infective drug development, today announced that Dr. Carl Gelhaus, Senior Program Manager of the Medical Countermeasures Division at MRIGlobal, will present positive interim data on Appili’s ATI-1701 program at the Chemical and Biological Defense Science & Technology Conference (CBD S&T). The conference is being held from November 18-21 at the Duke Energy Convention Center in Cincinnati, Ohio.

The poster presentation at CBD S&T will summarize the latest findings from the ongoing preclinical study of ATI-1701, which showed complete (100%) protection 90 days after vaccination from a lethal exposure to the pathogen Francisca tularensis. This time period is the longest vaccine protection period tested to date in this model. Researchers will conduct an additional evaluation of vaccine efficacy up to 365 days in the same model in H1 2020.  The U.S. Defense Threat Reduction Agency (DTRA), an arm of the U.S. Department of Defense (DOD), is funding this trial. MRI Global is managing the study under the DTRA contract HDTRA1-16-C-0028.

“Together with our partners at the DOD, MRIGlobal, and the National Research Council of Canada, we are greatly encouraged by results from the 90-day vaccine challenge study,” said Kevin Sullivan, CEO of Appili Therapeutics. “Although results are preliminary, they add to a growing body of evidence supporting advanced development of ATI-1701.  We look forward to sharing the 365-day challenge results next year, and working with our biodefense partners to potentially produce the first FDA-approved vaccine for the prevention of tularemia.”

Presentation details are as follows:

Title: Development of Francisella Tularensis SCHU S4 DeltaclpB as a Vaccine for the Prevention of Pneumonic Tularemia in the Warfighter

Session: Medical Countermeasures in the Context of a Layered Medical Defense

Date: Wednesday, November 20, 2019

Time: 4:00 p.m. – 6:00 p.m. ET

About ATI-1701

Appili is developing ATI-1701 as a vaccine to combat Francisella tularensis, which the U.S. National Institutes of Health (NIH) defines as a Category A pathogen (an organism that poses the highest risk to national security and public health). As it is 1,000 times more infectious than anthrax, experts consider the aerosolized form to have a high potential use in a bioterrorist attack.[i]  Several countries may already have operational weapons programs leveraging this pathogen, making the need for a vaccine to counter this biological weapons threat exceedingly important.[ii]

About the Chemical and Biological Defense Science & Technology Conference (CBD S&T)

DTRA will host the 2019 CBD S&T Conference at the Duke Energy Convention Center, in Cincinnati, Ohio, November 18-21, 2019. The conference provides the opportunity to collaborate with more than 1,500 scientists, program managers and leaders from across the globe who are committed to making the world safer by confronting chemical and biological defense challenges. Attendees will also network with DTRA science and technology managers as well as other members of DTRA’s Chemical and Biological Defense team.

About MRIGlobal

Celebrating its 75th year of business, MRIGlobal addresses some of the world’s greatest threats and challenges. Founded in 1944 as an independent, non-profit organization, we perform contract research for government, industry, and academia. Our customized solutions in national security and defense and health include research and development capabilities in clinical research support, infectious disease and biological threat agent detection, global biological engagement, in vitro diagnostics, and laboratory management and operations. MRIGlobal is one of two partners in the Alliance for Sustainable Energy, LLC, which manages and operates the National Renewable Energy Laboratory (NREL) in Golden, Colo., for the U.S. Department of Energy. For more information, visit www.mriglobal.org

About Appili Therapeutics

Appili Therapeutics, Inc. was founded to advance the global fight against infectious disease by matching clearly-defined patient needs with drug development programs that provide solutions to existing challenges patients, doctors, and society face in this challenging disease space. Appili has built pipeline of assets designed to address a broad range of significant unmet medical needs in the infectious disease landscape. This diverse pipeline aims to address some of the most urgent threats in global public health. Via an in-licensing program, Appili acquired the rights to ATI-1701, a vaccine for tularemia, being developed to mitigate the risks of a very serious biological weapons threat. ATI-1503 is a drug discovery program aimed at generating a novel class of antibiotics with broad-spectrum activity against Gram-negative superbugs. ATI-1501 employs Appili’s proprietary, taste-masked, oral-suspension technology with metronidazole for the growing number of patients with difficulty swallowing. Headquartered in Halifax, Nova Scotia, with offices in Mississauga, Ontario, Appili is pursuing worldwide opportunities in collaboration with science and industry commercial partners, governments and government agencies. For more information, visit www.AppiliTherapeutics.com.

This news release contains “forward-looking statements” which reflect the current expectations of the Company’s management future growth, results of operations, performance and business prospects and opportunities. Such statements include, but are not limited to, statements regarding the Company’s proposed development plans with respect to its product. Wherever possible, words such as “may “, “would “, “could “, “should”, “will,” “anticipate,” “believe,” “plan,” “expect,” “intend,” “estimate,” “potential for” and similar expressions have been used to identify these forward-looking statements. These statements reflect management’s current beliefs with respect to future events and are based on information currently available to management. Forward-looking statements involve significant risks, uncertainties and assumptions including with respect to the ability of the Company to adequately fund and implement its development plans and business strategy. Many factors could cause the Company’s actual results, performance or achievements to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements including, without limitation, those listed in the final prospectus of the Company dated June 12, 2019 and the other filings made by the Company with the Canadian securities regulatory authorities (which may be viewed at www.sedar.com). Should one or more of these risks or uncertainties materialize or should assumptions underlying the forward-looking statements prove incorrect, actual results, performance or achievements may vary materially from those expressed or implied by the forward-looking statements contained in this news release. These factors should be considered carefully, and prospective investors should not place undue reliance on the forward-looking statements. Although the forward-looking statements contained in the press release are based upon what management currently believes to be reasonable assumptions, the Company cannot assure prospective investors that actual results, performance or achievements will be consistent with these forward-looking statements. The Company disclaims any intention or obligation to revise forward-looking statements whether as a result of new information, future developments or otherwise, except as required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.

Neither the TSX Venture Exchange, nor its regulation services provider (as that term is defined in the policies of the exchange), accepts responsibility for the adequacy or accuracy of this release.




Investor Relations Contact:

Kimberly Stephens, CFO

Appili Therapeutics

E: [email protected]

Cablon Medical and Adaptiiv team up to expand reach of 3D printed medical accessories

Cablon Medical and Adaptiiv team up to expand the reach of 3D printed medical accessories for radiotherapy

HALIFAX, NS June 7, 2019 – Adaptiiv Medical Technologies Inc. (Adaptiiv) is pleased to announce that Cablon Medical, a leading developer and supplier of radiotherapy hardware and software, will become their latest Alliance Partner offering personalized 3D printed medical accessories in Belgium, The Netherlands, and Luxembourg. Cablon Medical and Adaptiiv will provide clinically viable solutions that focus on improving treatment and patient care.

As an Alliance Partner, Cablon Medical will be distributing Adaptiiv’s software solution to enable 3D printing of patient-specific bolus, for photon and electron radiotherapy treatment, as well as high dose rate (HDR) surface brachytherapy applicators. The Adaptiiv software solution integrates directly with existing treatment planning software, enabling practitioners to design and 3D print a patient-specific bolus or applicator. This innovative technique requires less fabrication time, replaces the need for complex bolus and expensive applicators, and provides an improved treatment and patient experience.

“Adaptiiv’s solution provides our clients with a method to improve the quality and efficiency of care as well as the patient experience,” said Peter Schoor, Vice President, Europe at Cablon Medical. Adaptiiv is the first company to offer a platform that seamlessly integrates into existing treatment workflows and their team has demonstrated the ability to rapidly validate new approaches to treatment that are being used in a clinical setting,” says Schoor.

In 2018, Adaptiiv became the first company in the world to receive US FDA 510(k) clearance and a CE Mark for a 3D printing software solution intended for use in radiation oncology. 3D printed accessories conform to the patient anatomy to improve radiation dose delivery, patients are more comfortable throughout the treatment period, and because the software fully integrates with treatment planning systems, setup and production times are drastically reduced.

“Cablon Medical and Adaptiiv are aligned in our vision of the importance of providing the highest standard of patient care. Our solution represents a step further to enabling patient-specific care by increasing the clinical acceptance and implementation of 3D printing at the point-of-care. To that end, we are excited to partner with Cablon Medical as our partnership provides reach into countries that will play a significant role in our efforts to provide patient-specific solutions to the global radiotherapy market,” says Peter Hickey, CEO of Adaptiiv.

About Adaptiiv
Adaptiiv Medical Technologies Inc. is the definitive software platform to design 3D printed medical accessories for use in radiation oncology. Headquartered in Halifax, Nova Scotia, Canada, Adaptiiv is shaping the future of patient-specific healthcare through innovation and collaboration with industry leaders throughout the world. Adaptiiv has FDA 510(k) clearance, is ISO 13485 certified, has a CE Mark, and TGA (Australia) approval. The company’s solution is currently used in nine countries including Canada, United States, Mexico, Australia, New Zealand, Israel, Hong Kong, Ireland, and England.

About Cablon Medical
Cablon Medical is a supplier of high-quality medical devices, medicines and consumables. In addition, Cablon Medical, develops innovative software and hardware for radiotherapy treatment and software for ultrasound image quality control. The products are sold both in The Netherlands and increasingly abroad.

Media Contact
Adaptiiv Medical Technologies Inc.

Rohit Seth
Director, Marketing
+1 (902) 442-9091
[email protected]

Cablon Medical B.V.
Cindy van Loen
Marketing Manager
+31 33 494 39 64
[email protected]

Related Links
Adaptiiv Medical Technologies Inc.
Cablon Medical B.V.

ENTREVESTOR: Adaptiiv Partners With Italy’s EZB

Read the full Entrevestor article here

Adaptiiv Medical Technologies Inc., the Halifax company that uses 3D printing to improve cancer treatment, has further extended its international reach by partnering with Italian peer Eckert & Ziegler BEBIG, or EZB.

EZB specializes in products used in brachytherapy, which applies radioactive sources directly to or into tumors while sparing the surrounding healthy tissue. For the patient, this means shorter treatment periods, fewer side effects and a faster recovery.

The two companies announced Sunday they will test and align their systems to provide an integrated workflow for cancer centers to create 3D-printed brachytherapy applicators customized to each patient. They believe the collaboration will demonstrate that 3D printing can provide clinically viable solutions that improve treatment and patient care.

“This is a significant milestone for us,” said Adaptiiv CTO Alex Dunphy in the press release.“Collaborating with the team at EZB has allowed us to continue to make significant strides towards improving the standard of care using a patient-specific approach in brachytherapy. The successful alignment of our systems will demonstrate that 3D printing can be used to provide a clinically viable solution in brachytherapy treatment.”